Indie frustration-peddler Surgeon Simulator was the game we were all swearing at in 2013 (shout-out to anyone who remembers when it was actually called Surgeon Simulator 2013). The initial version was made in 48 hours for the Global Game Jam, and Bossa Studios spent a further 48 days on getting the commercial version ready.
The sequel will be out next year, but though the trailer shows a bunch of Napoleon Dynamite-looking surgeons getting up to mischief it doesn't give away much about the actual game. According to the website (opens in new tab) there will be co-op and it sure does seem like it'll support four players.
Only the Epic storefront gets a logo in the trailer, and right now they're the only storefront with a page for it (opens in new tab).