There's modding and then there's meta-modding: re-imagining a game in an entirely new medium. YouTuber Many A True Nerd has redone the entire story of Fallout: New Vegas in a vast collection of annotated YouTube videos, à la Choose Your Own Adventure books. I've given it a few runs to remind myself of how very bad I am at choosing my own adventure.
Things are simplified, naturally. The outcome of shooting and sneaking is predetermined, so expect to die to deathclaws a lot. The feel of incomprehensible complexity is still there though: some players report having killed as few as two people on their way through the story. You'll need sound and annotations enabled to have your own crack at it.