D.S.A. has been in development for five years, and the result is a big, fun, enjoyably scrappy adventure game set in a bizarre world. You'll play as all three members of a separated girl group, solving puzzles by exploring and interacting with stuff, rather than trying every inventory item on every other inventory item ad nauseum. I like the "Low-Quality MSPaint Graphics" quite a lot; this feels like a lost game from before indie gaming exploded, something like Treasure Adventure Game or Eternal Daughter. (i.e. it's huge and fully featured, and rather ambitious.)
TOMBs of Reschette by Richard Goodness
I've been a bit lax in finding interactive fiction lately, so here's a good one from one of the genre's best writers, Richard Goodness. It's a joyously silly game set in a smallish dungeon, but one where you'll want to try every option to see what wonderfully bonkers endings you can uncover. TOMBs of Reschette is genuinely funny, something few games manage, and it makes great use of Twine. (Via Gnome)
Yume Nikki 3D by Zykov Eddy
A Yume Nikki fangame from Electric Highways developer Zykov Eddy, with a standalone expansion available in the same folder. What a moody world (well, worlds) to explore, from a novel, almost second-person perspective that constantly reminds us whose subconscious it is we're traipsing through. But mostly I like this because I like seeing pixel art in 3D games; Yume Nikki 3D is damned good at delivering that. (Via Warp Door)
Artners by Holly Gramazio
I like art creation games, not because I personally get much out of them, but because I know people are going to make some wonderful stuff. Artners gives you a subject, some time, and a set of tools with which to slop paint on your canvas; in a neat touch, another player can join in using the other side of the keyboard.
Mount Pleasant Drive by Niall Moody
I've not been to Glasgow, so for all I know it looks exactly like this strange, stationary trip through its streets, rivers, shops, parks, and other things I thought I saw in Niall Moody's "broken audiovisual radio". You move the mouse (I don't think you need to move the mouse, but it does speed things up) and the landscape contorts around you, taking you on a dreamlike/nightmarish journey around an urban place.