Nowadays, if there's a successful and moddable third-person action game, you can rest assured that eventually Nier: Automata's 2B will be modded into it. It happened recently with Sekiro, it's happened in Monster Hunter: World, and now (thank god!) you can play as 2B in Resident Evil 2 Remake.
The work of modder TXYI, the '2B Claire' mod does what the name implies: it replaces Claire with 2B. None of the movesets have changed—it doesn't change up the gameplay at all—but I can hardly imagine her moveset slotting nicely into the corridor-laden world of Resident Evil.
Here's a few more screenshots courtesy of mod uploader zhongyingjie.