This arrives in the wake of a Prey 2 GDC talk that was pulled just before the event. Eurogamer note a tweet from Human Head programmer Brian Karis which said that "Zenimax forced us to pull all Prey2 related talks from GDC."
Bethesda haven't confirmed or denied the suggestion that Prey 2 has been cancelled, offering only a "no comment" to Game Informer , which doesn't bode well. Publishers tend to be quite quick to insist that their games still exist. It'd be a shame if Prey 2 was dead. It had basically nothing to do with the original, but the open world cyberpunk crime-fighting premise sounded promising.